Evaluating Clinical Trial Designs for Investigational Treatments of Ebola Virus Disease

  title={Evaluating Clinical Trial Designs for Investigational Treatments of Ebola Virus Disease},
  author={Ben S. Cooper and Maciej F. Boni and Wirichada Pan-ngum and Nicholas P J Day and Peter Horby and Piero Olliaro and Trudie Lang and Nicholas J White and Lisa J. White and John Whitehead},
  booktitle={PLoS medicine},
BACKGROUND Experimental treatments for Ebola virus disease (EVD) might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic. METHODS AND FINDINGS A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA) with two or three stages, including both non-randomised and… CONTINUE READING
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