European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease

@article{Husby2012EuropeanSF,
  title={European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease},
  author={Steffen Husby and Sibylle Koletzko and I. R. Korponay-Szabó and M L Luisa Mearin and Alan D. Phillips and Raanan Shamir and Riccardo Troncone and Klaus Giersiepen and David Branski and Carlo Catassi and M Lelgeman and M. M{\"a}ki and Carmen Ribes-Koninckx and Alessandro Ventura and Klaus Peter Zimmer},
  journal={Journal of Pediatric Gastroenterology and Nutrition},
  year={2012},
  volume={54},
  pages={136–160}
}
Objective: Diagnostic criteria for coeliac disease (CD) from the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) were published in 1990. Since then, the autoantigen in CD, tissue transglutaminase, has been identified; the perception of CD has changed from that of a rather uncommon enteropathy to a common multiorgan disease strongly dependent on the haplotypes human leukocyte antigen (HLA)-DQ2 and HLA-DQ8; and CD-specific antibody tests have improved… Expand
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The aim of this study was to verify the prevalence of the HLA heterodimer and of theHLA DRB104 alleles in healthy subjects, in CD-affected children, and in other age-matched subjects affected by confounding disease from South Italy. Expand
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It is recommended that children and adolescents with symptoms of celiac disease or an increased risk for Celiac disease have a blood test for antibody to tissue transglutaminase (TTG), and that those with an elevated TTG be referred to a pediatric gastroenterologist for an intestinal biopsy and treated with a strict gluten-free diet. Expand
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The subclinical picture in 60% of the cases, the diagnostic delay, and the incidence of other autoimmune disorders suggest that routine screening of CD in TS is indicated, confirming the high prevalence of celiac disease in a large series of TS patients. Expand
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