European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease

@article{Husby2012EuropeanSF,
  title={European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease},
  author={Steffen Husby and Sibylle Koletzko and I. R. Korponay-Szabó and M L Luisa Mearin and Alan D. Phillips and Raanan Shamir and Riccardo Troncone and Klaus Giersiepen and David Branski and Carlo Catassi and M Lelgeman and M. M{\"a}ki and Carmen Ribes-Koninckx and Alessandro Ventura and Klaus Peter Zimmer},
  journal={Journal of Pediatric Gastroenterology and Nutrition},
  year={2012},
  volume={54},
  pages={136–160}
}
Objective: Diagnostic criteria for coeliac disease (CD) from the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) were published in 1990. Since then, the autoantigen in CD, tissue transglutaminase, has been identified; the perception of CD has changed from that of a rather uncommon enteropathy to a common multiorgan disease strongly dependent on the haplotypes human leukocyte antigen (HLA)-DQ2 and HLA-DQ8; and CD-specific antibody tests have improved… 

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CD diagnosis can be accurately established with or without duodenal biopsies if given recommendations are followed.
...

References

SHOWING 1-10 OF 175 REFERENCES

Discrimination between celiac and other gastrointestinal disorders in childhood by rapid human lymphocyte antigen typing.

The aim of this study was to verify the prevalence of the HLA heterodimer and of theHLA DRB104 alleles in healthy subjects, in CD-affected children, and in other age-matched subjects affected by confounding disease from South Italy.

Accuracy of Diagnostic Antibody Tests for Coeliac Disease in Children: Summary of an Evidence Report

IgA-EmA and IgA-anti-TG2/EmA tests appear highly accurate to diagnose coeliac disease in children and may help in excluding CD, while POC tests show inferior accuracy.

Accuracy and cost-effectiveness of a new strategy to screen for celiac disease in children with Down syndrome.

A new, accurate, and cost-sparing 2-step strategy for screening for celiac disease in patients with Down syndrome is proposed, based on selection of the individuals with potential CD by HLA-DQ typing and on longitudinal serologic CD screening in this selected group.

Orally Based Diagnosis of Celiac Disease: Current Perspectives

A review of studies that evaluated the possibility of using oral mucosa for the initial diagnosis of Celiac disease or for local gluten challenge shows that orally based diagnosis of CD is attractive and promising, although additional evaluations with standardized collection and analysis methods are needed.

Coeliac disease

The Marsh classification of intestinal coeliac lesions, as modified by Oberhuber et al, is used by most pathologists to evaluate the intestinal lesions of patients with CD, both for diagnosis and to assess the regression of the lesions after a gluten free diet.

Prevalence of Celiac disease among children in Finland.

The presence of serum tissue transglutaminase and endomysial autoantibodies is predictive of small-bowel abnormalities indicative of celiac disease and there is a good correlation betweenAutoantibody positivity and specific HLA haplotypes.

Human leukocyte antigens in Turkish pediatric celiac patients.

The study suggests that the human leukocyte antigen -A25(10) is a phenotype particularly encountered in Turkish pediatric celiac patients.

Celiac Disease: Evaluation of the Diagnosis and Dietary Compliance in Canadian Children

The clinical features at presentation as well as the associated disorders, family history, and evaluation of compliance with a gluten-free diet in children with celiac disease from across Canada are characterized.

Prevalence and clinical picture of celiac disease in Turner syndrome.

The subclinical picture in 60% of the cases, the diagnostic delay, and the incidence of other autoimmune disorders suggest that routine screening of CD in TS is indicated, confirming the high prevalence of celiac disease in a large series of TS patients.

Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study.

The results suggest that CD occurs frequently not only in patients with gastrointestinal symptoms, but also in first- and second-degree relatives and patients with numerous common disorders even in the absence of gastrointestinal symptoms.
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