Corpus ID: 74513859

European Association of Hospital Pharmacists (EAHP) Guidance on the Pharmacy Handling of Gene Medicines

@inproceedings{Vulto2007EuropeanAO,
  title={European Association of Hospital Pharmacists (EAHP) Guidance on the Pharmacy Handling of Gene Medicines},
  author={Arnold G. Vulto and Nicola S Stoner and Dip Clin Pharm and Ana Cerc{\'o}s and Torsten Hoppe-Tichy and Per Nydert and Andr{\'a}s Vermes and Andrea Wolfsberger},
  year={2007}
}
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17 Citations
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Methods Citations
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TLDR
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TLDR
Investigating time spend by hospital personnel in a drug change situation when dispensing medicine to in- and outpatients in a hospital setting in the Capital Region of Denmark finds that implementing drug changes do require extra time, thus, hospital management should encounter this and ensure that additional time is available for the hospital personnel to ensure a safe drug dispensing process. Expand
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TLDR
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Drug change: ‘a hassle like no other’. An in-depth investigation using the Danish patient safety database and focus group interviews with Danish hospital personnel
TLDR
Patient safety challenges related to DCs are identified and described to explore potential facilitators to improve patient safety in the medication process in Danish hospital setting, especially related to drug shortage. Expand
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction of DPYD and fluoropyrimidines
TLDR
This guideline describes the starting dose optimization of three anti-cancer drugs to decrease the risk of severe, potentially fatal, toxicity (such as diarrhoea, hand-foot syndrome, mucositis or myelosuppression) and directs DPYD testing prior to initiating fluoropyrimidines. Expand
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References

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Appendix 6 : Gene therapy
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TLDR
Key elements were Trust-wide communication and involvement of staff in a pro-active approach to risk management, with specific emphasis on staff training and engagement, waste management, audit and record keeping. Expand
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Results of various biological and physical/chemical tests of the urines or blood of health-care personnel working with cytotoxic drugs are discussed and protective measures have to be taken in order to lower the risk as much as possible. Expand
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It is shown that the level of organic content in the inactivation sample matrix has a significant impact on Virkon S activity, and it is proposed that Virk on S liquid decontamination procedures for adenovirus types 5 and 6 use 0.9% VirkOn S for contact times greater than five minutes. Expand
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TLDR
The genomes of human adenoviruses show considerably more chemical resistance than the complete viral particle, and the molecular resistance of individual serotypes also varies, but there was no clear correlation between the differences in the effect of disinfectants on infectivity of thecomplete viral particle and destruction of the viral genome. Expand
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The aim of this paper is to highlight the procedures used throughout the clinical trial process, including storage, handling and disposal of the vectors, to minimize the health and safety risk to staff, patients and the environment. Expand
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Despite few clear-cut successes thus far, gene therapy holds great promise for easing or curing a wide variety of protein-deficiency disorders.
Hospital and Pharmacy Departmental Policies and Procedures for Gene Therapy at a Teaching Institution
TLDR
These preliminary guidelines identify the standards of practice at one institution in 1999 and will be refined as systems of practice develop, which exemplify the types of precautions necessary for safely utilizing gene therapy. Expand
Primary Containment for Biohazards: Selection, Installation and Use of Biological Safety Cabinets
Emergency management/Emergency preparedness; Emergency management/Emergency response; Terrorism and threats/Biological terrorism
Virucidal efficacy of a combination of 0.2% peracetic acid and 80% (v/v) ethanol (PAA-ethanol) as a potential hand disinfectant.
TLDR
The broad antimicrobial spectrum including a high virucidal activity, short exposure time and no toxic or allergenic decomposition products are favourable prerequisites for the medical use of PAA-ethanol and it warrants further investigation as a hand disinfectant. Expand
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