Eurogin Roadmap: Comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix

  title={Eurogin Roadmap: Comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix},
  author={Maura Gillison and Xavier Castellsagué and Anil K. Chaturvedi and Marc T. Goodman and Peter J. F. Snijders and Massimo Tommasino and Marc Arbyn and Silvia Franceschi},
  journal={International Journal of Cancer},
The EUROGIN 2012 roadmap is focused on the comparative epidemiology of human papillomavirus (HPV) associated head and neck squamous cell cancers (HNSCC) and cervical cancers. Discussed are the similarities and differences between the two cancers with regard to global disease burden, HPV prevalence and type distribution, disease cofactors, molecular pathogenesis, treatment approaches, prognostic factors and primary and secondary prevention. The global incidence of HNSCC and cervical cancer is… 

Epidemiology of Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma.

Recent data are reviewed to provide insight into several topics, including incidence trends and projections for HPV-positive HNC; the worldwide HPV-attributable fraction; sex disparities in cancer risk; the epidemiology of oral HPV infection; the latency period between infection and cancer; the potential impact of prophylactic HPV vaccination; and prospects for secondary prevention.

Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis

The prevalence of HPV infection in European patients with head and neck cancers is high but varies between the different anatomical sites of these malignancies, and there appears to be no association between HPV type and geographical setting, type of samples analysed or type of primer used to analyse samples in such cancers.

Gender differences in the epidemiology and prevention of human papillomavirus (HPV) and HPV-related diseases

The gender perspective should be a strategic goal for medical research, education and for social and health policies, because it could lead to the formulation of more adequate prevention programmes, and the ability to treat patients fairly and appropriately with more targeted plans.

Role of mucosal high‐risk human papillomavirus types in head and neck cancers in central India

The data indicate that the proportion and types of mucosal HR‐HPV associated with HNC in this central Indian region differ from those in other (developed) parts of the world.

Current trends in the etiology and diagnosis of HPV-related head and neck cancers

Novel noninvasive approaches using oral fluid, a clinically relevant biological fluid, allow for the detection of HPV and cellular alterations in infected cells, which may aid in the early detection and HPV‐typing of HNSCC tumors.

Human Papillomavirus Induced Transformation in Cervical and Head and Neck Cancers

The cervical and head and neck cancer literature is reviewed to highlight clinical and genomic commonalities and differences in prognosis, staging and treatment, as well as comparisons of mutational profiles, viral integration patterns, and alterations in gene expression will be addressed.

Human papillomavirus genome variants and head and neck cancers: a perspective

The limited number of studies on HPV genome variants in head and neck cancers (HNC) are reviewed and their implications for cancer research are discussed, highlighting the main gaps of knowledge in the field of HPV-induced HNC.

EUROGIN 2014 roadmap: Differences in human papillomavirus infection natural history, transmission and human papillomavirus‐related cancer incidence by gender and anatomic site of infection

More research is needed to characterize HPV natural history at each anatomic site where HPV causes cancer in men and women, information that is critical to inform the basic science of HPVnatural history and the development of future infection and cancer prevention efforts.

Epidemiology of head and neck cancers: an update.

To decrease HNC incidence, measures to reduce tobacco use and alcohol consumption remain essential and improvement of HPV vaccination coverage is also a major objective.



EUROGIN 2011 roadmap on prevention and treatment of HPV‐related disease

Key findings in the field of cervical cancer prevention should now be translated in cost‐effective strategies, following an organized approach integrating primary and secondary prevention, according to scientific evidence but adapted to the local situation with particular attention to regions with the highest burden of disease.

Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.

It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.

The epidemiology of genital human papillomavirus infection.

Updating the natural history of human papillomavirus and anogenital cancers.

Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis.

HPV persistence was consistently and strongly associated with high-grade cervical intraepithelial neoplasia and CIN2-3/HSIL+, despite wide variation in definitions and study methods.

Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France--The EDiTH VI study.

  • J. L. St GuilyA. Jacquard F. Denis
  • Medicine
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2011

Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions.

The proportion of head and neck cancer caused by HPV may vary substantially between different geographical regions and studies that are designed to evaluate the impact of HPV vaccination on HNSCC need to consider this heterogeneity.

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

The presence of HPV in virtually all cervical cancers implies the highest worldwide attributable fraction so far reported for a specific cause of any major human cancer, and the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening.