EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

@inproceedings{Langerak2012EuroClonalityBIOMED2GF,
  title={EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations},
  author={Anton W. Langerak and P J T A Groenen and Monika Br{\"u}ggemann and Khe{\"i}ra Beldjord and C Bellan and Lilian Bonello and Elaine Boone and G I Carter and Mark Catherwood and Filippo Dav{\`i} and M-h Delfau-Larue and Tim C Diss and P A S Evans and Paula Gameiro and R Garcia Sanz and David Gonz{\'a}lez and Dan Grand and {\AA}sa H{\aa}kansson and Michael Hummel and H B Liu and Lidia Lombardia and Elizabeth A Macintyre and Benedict J Milner and Santiago Montes-Moreno and Ed Schuuring and Marcel Spaargaren and Ervin Hodges and Jacques J. M. van Dongen},
  booktitle={Leukemia},
  year={2012}
}
PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting. Standardization of the pre-analytical and post-analytical phases is now essential to prevent misinterpretation and incorrect conclusions derived from clonality data. As clonality testing is not a quantitative assay, but rather concerns recognition of molecular patterns, guidelines… CONTINUE READING
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