Euphorigenic doses of cocaine reduce [123I]β-CIT SPECT measures of dopamine transporter availability in human cocaine addicts

@article{Malison1995EuphorigenicDO,
  title={Euphorigenic doses of cocaine reduce [123I]β-CIT SPECT measures of dopamine transporter availability in human cocaine addicts},
  author={Robert Malison and Susan E. Best and Elinore McCance and Marc Laruelle and Ronald M. Baldwin and John Seibyl and Lawrence H. Price and Thomas R. Kosten and Robert B. Innis and Paul B. Hoffer and Sami S. Zoghbi and Elizabeth A Wallace},
  journal={Psychopharmacology},
  year={1995},
  volume={122},
  pages={358-362}
}
The in vivo potency of euphorigenic doses of intravenous cocaine for displacing [123I]β-CIT ([123I]2β-carbomethoxy-3β-(4-iodophenyl)tropane) binding to striatal dopamine transporters (DAT) was assessed in human cocaine addicts using single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n=6) were injected with [123I]β-CIT and imaged 24 h later under equilibrium conditions. Sequential cocaine infusions (0.28±0.03 and 0.56±0.07 mg/kg) produced significant (P<0.0005… CONTINUE READING

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