Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis.

@article{Lin2012EupholFE,
  title={Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis.},
  author={M. W. Lin and A L Lin and Deng-Chyang Wu and Sophie S. W. Wang and F. -H. Chang and Yang-Chang Wu and Yaw-Bin Huang},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2012},
  volume={50 12},
  pages={4333-9}
}
Gastric cancer is one of the most common malignancies worldwide, and the main cause of cancer-related death in Asia. The present study assessed the anticancer effects of euphol, a triterpene alcohol with anti-inflammatory and antiviral activities on human gastric cancer cells. Euphol showed higher cytotoxicity activity against human gastric CS12 cancer cells than against noncancer CSN cells. In addition, it up-regulated the pro-apoptotic protein BAX and down-regulated the prosurvival protein… CONTINUE READING

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Highly Influential
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Food and Chemical Toxicology xxx

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