Eupatorium cannabinum L.

  title={Eupatorium cannabinum L.},
  author={Herman J. Woerdenbag},
  journal={Pharmaceutisch Weekblad},
  • H. J. Woerdenbag
  • Published 1 October 1986
  • Chemistry, Medicine
  • Pharmaceutisch Weekblad
A review onEupatorium cannabinum L. is given, including botany, history and constituents. The sesquiterpene lactones are discussed in more detail, covering their biosynthesis, isolation, analysis and biological activity. Special attention is paid to the cytotoxic and antitumour activities of the sesquiterpene lactones. 
Flavones and flavonol glycosides fromEupatorium cannabinum L.
The 6-methoxyflavones hispidulin and eupafolin have been identified for the first time from the aerial parts ofEupatorium cannabinum L. The presence of the previously known flavonol glycosidesExpand
New Gemacranolides from Eupatorium hualienense
The isolation of the new sesquiterpene lactones 1–5, named eupahualins A–E, along with the known heliangolide eupasimplicin B, showed significant activities against cell lines of human chronic myelogenous leukemia and human bone cancer. Expand
Sesquiterpene lactones of Eupatorium cannabinum
To isolate the substances that had been detected, the comminuted raw material was extracted with a tenfold amount of chloroform, and then the solvent was evaporated off and the sesquiterpene lactonesExpand
Eupatozansins A – C, Sesquiterpene Lactones from Eupatorium chinense var. tozanense
Phytochemical investigation of Eupatorium chinense var. tozanense has resulted in the isolation of three new germacranolides, designated as eupatozansins A–C (1–3), along with five known compounds,Expand
Pharmacological activity of an Eupatorium cannabinum L. extract
Pharmacological activity of Eupatorium cannabinum L. hydroalcoholic extract have been studied with the use of two in vitro assays - DPPH reduction spectrophotometric assay, and evaluation ofExpand
Analysis of the essential oil from aerial parts of Eupatorium cannabinum subsp. corsicum (L.) by gas chromatography with electron impact and chemical ionization mass spectrometry.
The essential oil from aerial parts of E. corsicum was studied by GC, GC/MS and 13C NMR and a particularity of this essential oil is the presence of monoterpene esters derived from nerol, lavandulol, borneol, thymol and 8,9-dehydrothymol. Expand
A new group of plants, from the "Useful Plants" sub-section, less known for its immunostimulant proprieties, but which are used in the composition of some modern drugs (neutraceuticals) are presented. Expand
Analysis of the essential oil from the roots of Eupatorium cannabinum subsp. corsicum (L.) by GC, GC-MS and 13C-NMR.
The essential oil from the roots of this aromatic plant has been studied by GC, GC-MS and by 13C-NMR and was characterized by a high content of oxygenated compounds, particularly oxygenated monoterpenes. Expand
Bioactive-guided Identification of Labdane Diterpenoids from Aerial Parts of Aristeguietia glutinosa as anti-Trypanosoma cruzi agents
Labdene 1, equipotent as the reference compound (Nifurtimox), displayed low hemolytic activity, low toxicity against murine macrophages, and absence of mutagenicity, which support the vernacular medicinal use of this plant as an anti-T. Expand
Variability, toxicity, and antioxidant activity of Eupatorium cannabinum (hemp agrimony) essential oils
Investigation on pharmacological properties (antioxidant and toxic activities) of essential oils of E. cannabinum, collected from 11 wild populations in Lithuania, provided some new data concerning chemical composition and pharmaceutical properties of the plant. Expand


Neue sesquiterpenlactone und andere inhaltsstoffe aus vertretern der Eupatorium-gruppe☆
Abstract The investigation of twelve further species of the Eupatorium complex affords four new germacrolides and seven guaianolides together with new thymol and p-hydroxyacetophenone derivatives.Expand
Antitumor agents. II. Eupatolide, a new cytotoxic principle from Eupatorium formosanum HAY.
An alcoholic extract of the aboveground parts of Eupatorium formosanum, which showed significant inhibitory activity of the in vitro growth of tissue culture cells derived from human epidermoidExpand
The Biogenesis and Chemistry of Sesquiterpene Lactones
It is the major goal of this review to present the presently known naturally occurring sesquiterpene lactones and their distribution in the plant kingdom. Furthermore, biogenetic hypothesesExpand
Biological activities of sesquiterpene lactones
A review of the present state of knowledge on the biological activities and mechanism of action of some sesquiterpene lactones highlighted in Compositae and other angiosperm families and even in some liverworts. Expand
Hiyodorilactones D,E, and F, new cytotoxic sesquiterpene lactones from Eupatorium sachalinense Makino.
Three new cytotoxic germacranolides, hiyodorilactones D, E, and F were isolated from the leaves of Eupatorium sachalinense MAKINO, and their structures were determined to be 4, 5, and 6,Expand
Sesquiterpene lactones XVII. Cytostatic and pharmacological activity.
Of four lactones studied in the systems Sa-180, EAC and L-1210, two compounds: alatolide, (ALA) and eupatoriopicrin (EUPP), according to the criteria of CCNSC, showed high cytostatic activity, andExpand
Dammaradienyl acetate and taraxasterol from Eupatorium cannabinum: Mass spectrometric study of dammaradienyl acetate and its derivatives
Dammaradienyl acetate (1) (0.01%), taraxasterol (6) (0.0008%) and stigmasterol (c. 0.005%) have been isolated from the whole plant of Eupatorium cannabinum (Compositae). A mass spectrometric study ofExpand
Eucannabinolide and other constituents of Schkuhria virgata
Abstract Isolation of eucannabinolide, its 3-isovaleroyl analog and pectolinarigenin from Schkuhria virgata (La Llave et Lex.) DC. is reported. The identity of eucannabinolide, which exhibits in vivoExpand
Seven guaianolides from Eupatorium chinense
Abstract Two allyl hydroperoxy guaianolide sesquiterpene lactones (peroxyeupahakonin-A and -B) and five new guaianolides (eupahakonin-A and -B, eupahakonenin-A and -B, and eupahakonesin) wereExpand
Structure-activity relationships among in vivo active germacranolides.
Nine structurally related germacranolides were assayed in two standard tumor systems and the moieties necessary for in vivo activity were found to be an alpha,beta-unsaturated ester side chain adjacent to the gamma-lactone and either a primary or secondary allylic alcohol or both. Expand