Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.

@article{Das2001EukaryoticTI,
  title={Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.},
  author={Supratik Das and Ratna Ghosh and Umadas Maitra},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 9},
  pages={6720-6}
}
Eukaryotic translation initiation factor 5 (eIF5) forms a complex with eIF2 by interacting with the beta subunit of eIF2. This interaction is essential for eIF5-promoted hydrolysis of GTP bound to the 40 S initiation complex. In this work, we show that, in addition to the eIF2 beta-binding region at the C terminus of eIF5, the N-terminal region of eIF5 is also required for eIF5-dependent GTP hydrolysis. Like other GTPase-activating proteins, eIF5 contains an invariant arginine residue (Arg-15… CONTINUE READING

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