Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation.

@article{Svitkin2005EukaryoticTI,
  title={Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation.},
  author={Yuri V. Svitkin and Barbara Herdy and Mauro Costa-Mattioli and Anne-Claude Gingras and Brian Raught and Nahum Sonenberg},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 23},
  pages={10556-65}
}
Translation of m7G-capped cellular mRNAs is initiated by recruitment of ribosomes to the 5' end of mRNAs via eukaryotic translation initiation factor 4F (eIF4F), a heterotrimeric complex comprised of a cap-binding subunit (eIF4E) and an RNA helicase (eIF4A) bridged by a scaffolding molecule (eIF4G). Internal translation initiation bypasses the requirement for the cap and eIF4E and occurs on viral and cellular mRNAs containing internal ribosomal entry sites (IRESs). Here we demonstrate that… CONTINUE READING

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