Eukaryotic transcriptional control.

@article{Kornberg1999EukaryoticTC,
  title={Eukaryotic transcriptional control.},
  author={Roger D. Kornberg},
  journal={Trends in cell biology},
  year={1999},
  volume={9 12},
  pages={M46-9}
}
Some 30 years ago, following the elucidation of transcriptional control in prokaryotes, attention turned to the corresponding problem in eukaryotes: how are so many genes transcribed in a cell-type-specific, developmentally regulated manner? The answer has been found in two modes of regulation, one involving chromatin and the other the chief transcribing enzyme, RNA polymerase II. Although basic features of the prokaryotic mechanism have been preserved, the demands of eukaryotic transcription… CONTINUE READING

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