Eukaryotic rpL10 drives ribosomal rotation

  title={Eukaryotic rpL10 drives ribosomal rotation},
  author={Sergey O. Sulima and Suna P. G{\"u}lay and Margarida Anjos and Stephanie Patchett and Arturas Meskauskas and Arlen W Johnson and Jonathan D. Dinman},
  booktitle={Nucleic acids research},
Ribosomes transit between two conformational states, non-rotated and rotated, through the elongation cycle. Here, we present evidence that an internal loop in the essential yeast ribosomal protein rpL10 is a central controller of this process. Mutations in this loop promote opposing effects on the natural equilibrium between these two extreme conformational states. rRNA chemical modification analyses reveals allosteric interactions involved in coordinating intersubunit rotation originating from… CONTINUE READING
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