Eukaryotic rpL10 drives ribosomal rotation

@inproceedings{Sulima2014EukaryoticRD,
  title={Eukaryotic rpL10 drives ribosomal rotation},
  author={Sergey O. Sulima and Suna P. G{\"u}lay and Margarida Anjos and Stephanie Patchett and Arturas Meskauskas and Arlen W Johnson and Jonathan D. Dinman},
  booktitle={Nucleic acids research},
  year={2014}
}
Ribosomes transit between two conformational states, non-rotated and rotated, through the elongation cycle. Here, we present evidence that an internal loop in the essential yeast ribosomal protein rpL10 is a central controller of this process. Mutations in this loop promote opposing effects on the natural equilibrium between these two extreme conformational states. rRNA chemical modification analyses reveals allosteric interactions involved in coordinating intersubunit rotation originating from… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 78 references

Crystal structure of the 80S yeast ribosome

  • L. Jenner, S. Melnikov, +7 authors M. Yusupov
  • Curr. Opin. Struct. Biol.,
  • 2012

Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits

  • S. Lebaron, C. Schneider, +6 authors D. Tollervey
  • Nat. Struct. Mol. Biol.,
  • 2012

Similar Papers

Loading similar papers…