Eukaryotic ribosomal RNA: the recent excitement in the nucleotide modification problem

@article{Maden1997EukaryoticRR,
  title={Eukaryotic ribosomal RNA: the recent excitement in the nucleotide modification problem},
  author={B. Edward H. Maden and John M. X. Hughes},
  journal={Chromosoma},
  year={1997},
  volume={105},
  pages={391-400}
}
Eukaryotic ribosomal RNA (rRNA) contains numerous modified nucleotides: about 115 methyl groups and some 95 pseudouridines in vertebrates; about 65 methyl groups and some 45 pseudouridines inSaccharomyces cerevisiae. All but about ten of the methyl groups are ribose methylations. The remaining ten are on heterocyclic bases. The ribose methylations occur very rapidly upon the primary rRNA transcript in the nucleolus, prabably on nascent chains, and they appear to play an important role in… CONTINUE READING

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BEH Maden
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