Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins.

@article{Li2013EukaryoticRT,
  title={Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins.},
  author={Sanshu Li and Kathryn D. Smith and Jared Heaton Davis and Patricia B Gordon and Ronald R. Breaker and Scott A Strobel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 47},
  pages={
          19018-23
        }
}
Fluorine is an abundant element and is toxic to organisms from bacteria to humans, but the mechanisms by which eukaryotes resist fluoride toxicity are unknown. The Escherichia coli gene crcB was recently shown to be regulated by a fluoride-responsive riboswitch, implicating it in fluoride response. There are >8,000 crcB homologs across all domains of life, indicating that it has an important role in biology. Here we demonstrate that eukaryotic homologs [renamed FEX (fluoride exporter)] function… CONTINUE READING

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CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

The accumulation of fluorine by plants.

  • Journal of the Air Pollution Control Association
  • 1966
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL

Fluoride resistance and transport by riboswitch-controlled CLC antiporters.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012
VIEW 1 EXCERPT