Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions.

@article{Johnson2000EukaryoticPI,
  title={Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions.},
  author={Robert E. Johnson and M. Todd Washington and Lajos Haracska and Satya Prakash and L. T. Om Prakash},
  journal={Nature},
  year={2000},
  volume={406 6799},
  pages={1015-9}
}
DNA lesions can often block DNA replication, so cells possess specialized low-fidelity, and often error-prone, DNA polymerases that can bypass such lesions and promote replication of damaged DNA. The Saccharomyces cerevisiae RAD30 and human hRAD30A encode Pol eta, which bypasses a cis-syn thymine-thymine dimer efficiently and accurately. Here we show that a related human gene, hRAD30B, encodes the DNA polymerase Pol iota, which misincorporates deoxynucleotides at a high rate. To bypass damage… CONTINUE READING