Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology

  title={Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology},
  author={Sarah C. Shuck and Emily Short and John J Turchi},
  journal={Cell Research},
Repair of bulky DNA adducts by the nucleotide excision repair (NER) pathway is one of the more versatile DNA repair pathways for the removal of DNA lesions. There are two subsets of the NER pathway, global genomic-NER (GG-NER) and transcription-coupled NER (TC-NER), which differ only in the step involving recognition of the DNA lesion. Following recognition of the damage, the sub-pathways then converge for the incision/excision steps and subsequent gap filling and ligation steps. This review… CONTINUE READING

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