Eukaryotic localization, activation and ubiquitinylation of a bacterial type III secreted toxin.

@article{Stirling2006EukaryoticLA,
  title={Eukaryotic localization, activation and ubiquitinylation of a bacterial type III secreted toxin.},
  author={Fiona R Stirling and Alayne Cuzick and Sharon M Kelly and David Oxley and Thomas J Evans},
  journal={Cellular microbiology},
  year={2006},
  volume={8 8},
  pages={
          1294-309
        }
}
Type III secretion is a widespread method whereby Gram-negative bacteria introduce toxins into eukaryotic cells. These toxins mimic or subvert a normal cellular process by interacting with a specific target, although how toxins reach their site of action is unclear. We set out to investigate the intracellular localization of a type III toxin of Pseudomonas aeruginosa called ExoU, which has phospholipase activity and requires a eukaryotic factor for activity. We found that ExoU is localized to… CONTINUE READING
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