Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection.

@article{Svitkin1999EukaryoticIF,
  title={Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection.},
  author={Yuri V. Svitkin and Alessandra Gradi and Hiroaki Imataka and Shigenobu Morino and Nahum Sonenberg},
  journal={Journal of virology},
  year={1999},
  volume={73 4},
  pages={3467-72}
}
For many members of the Picornaviridae family, infection of cells results in a shutoff of host protein synthesis. For rhinoviruses and enteroviruses, the shutoff has been explained in part by the cleavage of eukaryotic initiation factor 4GI (eIF4GI), a component of the cap-binding protein complex eIF4F. The cleavage of eIF4GI is mediated by the virus-specific proteinase 2Apro and results in inhibition of cap-dependent, but not cap-independent, translation. The inhibition of host protein… CONTINUE READING
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