Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

@article{Hernndez2012EukaryoticIF,
  title={Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.},
  author={Georgina Hern{\'a}ndez and Hong Ryul Han and Valentina Gandin and Lacramioara Fabian and Tiago Emanuel Silva Ferreira and Joanna Żuberek and Nahum Sonenberg and Julie A Brill and Paul Lasko},
  journal={Development},
  year={2012},
  volume={139 17},
  pages={
          3211-20
        }
}
Gene expression is translationally regulated during many cellular and developmental processes. Translation can be modulated by affecting the recruitment of mRNAs to the ribosome, which involves recognition of the 5' cap structure by the cap-binding protein eIF4E. Drosophila has several genes encoding eIF4E-related proteins, but the biological role of most of them remains unknown. Here, we report that Drosophila eIF4E-3 is required specifically during spermatogenesis. Males lacking eIF4E-3 are… CONTINUE READING
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