Eukaryotic gene regulation in three dimensions and its impact on genome evolution.

@article{Babu2008EukaryoticGR,
  title={Eukaryotic gene regulation in three dimensions and its impact on genome evolution.},
  author={M. Madan Babu and Sarath Chandra Janga and In{\^e}s de Santiago and Ana Pombo},
  journal={Current opinion in genetics & development},
  year={2008},
  volume={18 6},
  pages={571-82}
}
Recent advances in molecular techniques and high-resolution imaging are beginning to provide exciting insights into the higher order chromatin organization within the cell nucleus and its influence on eukaryotic gene regulation. This improved understanding of gene regulation also raises fundamental questions about how spatial features might have constrained the organization of genes on eukaryotic chromosomes and how mutations that affect these processes might contribute to disease conditions… CONTINUE READING

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