Eukaryotic gene expression: metabolite control by amino acids.

  title={Eukaryotic gene expression: metabolite control by amino acids.},
  author={Roney O. Laine and Richard G. Hutson and Michael S. Kilberg},
  journal={Progress in nucleic acid research and molecular biology},
Our understanding of the metabolite control in mammalian cells lags far behind that in prokaryotes. This is particularly true for amino-acid-dependent gene expression. Few proteins have been identified for which synthesis is selectively regulated by amino-acid availability, and the mechanisms for control of transcription and translation in response to changes in amino-acid availability have not yet been elucidated. The intimate relationship between amino-acid supply and the fundamental cellular… CONTINUE READING

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