Eukaryotic cytosine methyltransferases.

@article{Goll2005EukaryoticCM,
  title={Eukaryotic cytosine methyltransferases.},
  author={Mary Grace Goll and Timothy H Bestor},
  journal={Annual review of biochemistry},
  year={2005},
  volume={74},
  pages={
          481-514
        }
}
  • Mary Grace Goll, Timothy H Bestor
  • Published 2005
  • Medicine, Biology
  • Annual review of biochemistry
  • Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylation does not reinforce or replace ancestral gene regulation pathways but instead endows methylated genomes with the ability to repress specific promoters in a manner that is buffered against changes in the internal and external environment. Recent studies have shown that the targeting of de novo methylation depends on multiple inputs… CONTINUE READING

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