Eukaryotic activators function during multiple steps of preinitiation complex assembly

@article{Choy1993EukaryoticAF,
  title={Eukaryotic activators function during multiple steps of preinitiation complex assembly},
  author={Bob Choy and Michael R. Green},
  journal={Nature},
  year={1993},
  volume={366},
  pages={531-536}
}
Eukaryotic activator proteins (activators) stimulate transcription by increasing assembly of the preinitiation complex. We have developed methods to quantify the stable assembly of general transcription factors into transcriptional complexes in response to activators. We show that activators function during at least two stages of preinitiation complex assembly: first, to recruit the general transcription factor TFIIB, and then at a second step, after TFIIB entry. It is at this second step that… CONTINUE READING

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