Eukaryotic Translation Initiation Factor 4A Down-Regulation Mediates Interleukin-24-Induced Apoptosis through Inhibition of Translation

@inproceedings{Zhong2018EukaryoticTI,
  title={Eukaryotic Translation Initiation Factor 4A Down-Regulation Mediates Interleukin-24-Induced Apoptosis through Inhibition of Translation},
  author={Xuelin Zhong and Leah Persaud and Hilal Muharam and Ashleigh Francis and Dibash Das and Bertal H Aktas and Moira Sauane},
  booktitle={Cancers},
  year={2018}
}
Dysregulated activity of helicase eIF4A drives transformation to and maintenance of cancer cell phenotype by reprogramming cellular translation. Interleukin 24 (IL-24) is a tumor-suppressing protein, which has the ability to inhibit angiogenesis, sensitize cancer cells to chemotherapy, and induce cancer cell-specific apoptosis. In this study, we found that… CONTINUE READING