Eukaryotic Ribosome Assembly.

  title={Eukaryotic Ribosome Assembly.},
  author={Jochen Ba{\ss}ler and Ed Hurt},
  journal={Annual review of biochemistry},
Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal proteins, which coassemble hierarchically during a process termed ribosome biogenesis. Historically, biochemical and molecular biology approaches have revealed how preribosomal particles form and mature in consecutive steps, starting in the nucleolus and terminating after nuclear export into the cytoplasm. However, only recently, due to the revolution in cryo-electron microscopy, could pseudoatomic… 

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Insight is gained into the formation of eukaryotic ribosomes by determining cryo–electron microscopy structures of Saccharomyces cerevisiae intermediates in the path from the 90S to the pre-40S, revealing key intermediates and the critical role of 5′ ETS degradation in 90S progression.