Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

@article{Liu1981EukaryoticDT,
  title={Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.},
  author={Leroy F. Liu and Kedrick Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 6},
  pages={3487-91}
}
Two type I DNA topoisomerases have been purified to homogeneity from the nuclei of HeLa cells. One topoisomerase has a peptide molecular weight of 100,000 and the other, a molecular weight of 67,000. Several lines of evidence indicate that these two topoisomerases are closely related, (a) Both exhibit similar enzymatic activities on DNA. (b) The chromatographic properties of the two topoisomerases during purification are similar. (c) Mild proteolysis of the purified molecular weight 100,000… CONTINUE READING

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