Eukaryotic Chaperonins: Lubricating the Folding of WD-repeat Proteins

Abstract

For most proteins of the eukaryotic cytosol, the folding pathways are still largely a mystery, even though many cytosolic chaperones have been identified, including multiple members of the heat shock protein (Hsp) 70 family, Hsp90 and the chaperonin, CCT/TRiC. Particularly puzzling has been the role of CCT, a distant cousin of the prokaryotic chaperonin… (More)
DOI: 10.1016/j.cub.2003.11.009

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