Eugenol dilates rat cerebral arteries by inhibiting smooth muscle cell voltage-dependent calcium channels.

@article{PeixotoNeves2014EugenolDR,
  title={Eugenol dilates rat cerebral arteries by inhibiting smooth muscle cell voltage-dependent calcium channels.},
  author={Dieniffer Peixoto-Neves and Jos{\'e} Henrique Leal-Cardoso and Jonathan H Jaggar},
  journal={Journal of cardiovascular pharmacology},
  year={2014},
  volume={64 5},
  pages={401-6}
}
Plants high in eugenol, a phenylpropanoid compound, are used as folk medicines to alleviate diseases including hypertension. Eugenol has been demonstrated to relax conduit and ear arteries and reduce systemic blood pressure, but mechanisms involved are unclear. Here, we studied eugenol regulation of resistance-size cerebral arteries that control regional brain blood pressure and flow and investigated mechanisms involved. We demonstrate that eugenol dilates arteries constricted by either… CONTINUE READING
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