Eugenol activates Ca(2+)-permeable currents in rat dorsal root ganglion cells.

@article{Ohkubo1997EugenolAC,
  title={Eugenol activates Ca(2+)-permeable currents in rat dorsal root ganglion cells.},
  author={Tsuyako Ohkubo and Kazuo Kitamura},
  journal={Journal of dental research},
  year={1997},
  volume={76 11},
  pages={1737-44}
}
Although little is known about the mechanism of action of eugenol, some related compounds have been compared with capsaicin derivatives in terms of the relationship between their chemical structure and activity. To elucidate whether eugenol and capsaicin act via a common mechanism at the neuronal membrane, we investigated the effects of eugenol on rat DRG neurons using the whole-cell patch-clamp technique. Eugenol (0.125-1 mmol/L) produced an inward current in a concentration-dependent manner… CONTINUE READING

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