Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells.

@article{Raghavenra2006EugenoltheAP,
  title={Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells.},
  author={H. Raghavenra and B. T. Diwakr and B. Lokesh and K. Naidu},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={2006},
  volume={74 1},
  pages={
          23-7
        }
}
  • H. Raghavenra, B. T. Diwakr, +1 author K. Naidu
  • Published 2006
  • Chemistry, Medicine
  • Prostaglandins, leukotrienes, and essential fatty acids
  • Polymorphonuclear leukocytes (PMNL) play an important role in the modulation of inflammatory conditions in humans. PMNL cells recruited at the site of inflammation, release inflammatory mediators such as leukotrienes, proteolytic enzymes and reactive oxygen species. Among these, leukotrienes are implicated in pathophysiology of allergic and inflammatory disorders like asthma, allergic rhinitis, arthritis, inflammatory bowel disease and psoriasis. 5-lipoxygenase (5-LO) is the key enzyme in… CONTINUE READING
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