Eudragits: role as crystallization inhibitors in drug-in-adhesive transdermal systems of estradiol.

@article{Kotiyan2001EudragitsRA,
  title={Eudragits: role as crystallization inhibitors in drug-in-adhesive transdermal systems of estradiol.},
  author={Pramila N Kotiyan and Pradeep Ratilal Vavia},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2001},
  volume={52 2},
  pages={
          173-80
        }
}
A transdermal steroidal delivery system usually contains a high concentration of drug to obtain high drug fluxes. The present investigation involved the development of drug-in-adhesive transdermal systems of estradiol using synthesized acrylate copolymer (EA) of 2-ethylhexyl acrylate and acrylic acid. The effect of several variables such as varying drug polymer ratios, effect of Eudragit RL PO and Eudragit E PO and effect of drying temperatures on prevention of drug crystallization in the… CONTINUE READING

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