Eucapnic intermittent hypoxia augments endothelin-1 vasoconstriction in rats: role of PKCdelta.

@article{Allahdadi2008EucapnicIH,
  title={Eucapnic intermittent hypoxia augments endothelin-1 vasoconstriction in rats: role of PKCdelta.},
  author={Kyan J Allahdadi and Laura C Duling and Benjimen R. Walker and Nancy Lapp Kanagy},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 2},
  pages={H920-7}
}
We reported previously that simulating sleep apnea by exposing rats to eucapnic intermittent hypoxia (E-IH) causes endothelin-dependent hypertension and increases constrictor sensitivity to endothelin-1 (ET-1). In addition, augmented ET-1-induced constriction in small mesenteric arteries (sMA) is mediated by increased Ca(2+) sensitization independent of Rho… CONTINUE READING