Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine.

Abstract

Recently, it was shown that the exposure to the potent hop phytoestrogen 8-prenylnaringenin (8-PN) depends on intestinal bacterial activation of isoxanthohumol (IX), but this occurs in only one-third of tested individuals. As the butyrate-producing Eubacterium limosum can produce 8-PN from IX, a probiotic strategy was applied to investigate whether 8-PN… (More)

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@article{Possemiers2008EubacteriumLA, title={Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine.}, author={Sam Possemiers and Sylvie Rabot and Juan Carlos Esp{\'i}n and Aur{\'e}lia Bruneau and Catherine Philippe and Antonio Gonz{\'a}lez-Sarr{\'i}as and Arne Heyerick and Francisco A Tom{\'a}s-Barber{\'a}n and Denis de Keukeleire and Willy Verstraete}, journal={The Journal of nutrition}, year={2008}, volume={138 7}, pages={1310-6} }