Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

  title={Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis},
  author={Benson Lu and Cristina Cebri{\'a}n and Xuan Chi and Satu Kuure and Richard Kuo and Carlton M. Bates and Silvia Arber and J. Hassell and Lesley T MacNeil and Masato Hoshi and Sanjay Jain and Naoya Asai and Masahide Takahashi and Kai M Schmidt-Ott and Jonathan Barasch and Vivette D D'agati and Frank D. Costantini},
  journal={Nature Genetics},
Glial cell line–derived neurotrophic factor signaling through the Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet few of the downstream genes are known. Here we show that the ETS transcription factors Etv4 and Etv5 are positively regulated by Ret signaling in the ureteric bud tips. Mice lacking both Etv4 alleles and one Etv5 allele show either renal agenesis or severe hypodysplasia, whereas kidney development fails completely in… CONTINUE READING


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