Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc.

@article{Xu2008Ets2MH,
  title={Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc.},
  author={Dakang Xu and Julie M Dwyer and He Xiao Li and Wei Duan and Jun Liu},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 35},
  pages={23567-80}
}
Human telomerase reverse transcriptase (hTERT) underlies cancer cell immortalization, and the expression of hTERT is regulated strictly at the gene transcription. Here, we report that transcription factor Ets2 is required for hTERT gene expression and breast cancer cell proliferation. Silencing Ets2 induces a decrease of hTERT gene expression and increase in human breast cancer cell death. Reconstitution with recombinant hTERT rescues the apoptosis induced by Ets2 depression. In vitro and in… CONTINUE READING
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Ets2 Binds c-Myc in Regulating hTERT Gene Expression

  • S. Svensson, K. Jirstrom, L. Ryden, G. Roos, S. Emdin, M. C. Ostrowski
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Ets2 Binds c-Myc in Regulating hTERT Gene Expression 23580 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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