Ets1 Is an Effector of the Transforming Growth Factor β (TGF-β) Signaling Pathway and an Antagonist of the Profibrotic Effects of TGF-β

@inproceedings{CzuwaraLadykowska2002Ets1IA,
  title={Ets1 Is an Effector of the Transforming Growth Factor β (TGF-β) Signaling Pathway and an Antagonist of the Profibrotic Effects of TGF-β},
  author={Joanna Czuwara-Ladykowska and Victor I. Sementchenko and Dennis K. Watson and Maria Trojanowska},
  year={2002}
}
Abstract Extracellular matrix (ECM) production and turnover are tightly controlled under normal physiological conditions. Ets factors regulate matrix turnover by activating transcription of several metalloproteinases (MMPs) and are frequently overexpressed in aggressive tumors and arthritis. Because of the prominent role of transforming growth factor β (TGF-β) in ECM synthesis, this study was undertaken to determine the possible interactions between Ets1 and the TGF-β pathway. Experiments using… CONTINUE READING

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  • 2005
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