Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.

@article{Zhu2011EtsTF,
  title={Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.},
  author={Sijun Zhu and Suzanne Barshow and Jill Wildonger and Yuh Nung Jan and Yasushi Jan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 51},
  pages={
          20615-20
        }
}
Intermediate neural progenitor (INP) cells are transient amplifying neurogenic precursor cells generated from neural stem cells. Amplification of INPs significantly increases the number of neurons and glia produced from neural stem cells. In Drosophila larval brains, INPs are produced from type II neuroblasts (NBs, Drosophila neural stem cells), which lack the proneural protein Asense (Ase) but not from Ase-expressing type I NBs. To date, little is known about how Ase is suppressed in type II… CONTINUE READING
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