Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.

@article{Baker2003Ets2AC,
  title={Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.},
  author={Kimberly M Baker and Guo Wei and Alicia Erbe Schaffner and Michael C. Ostrowski},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 20},
  pages={17876-84}
}
Ets-2 is a transcriptional activator that can be modulated by ras-dependent phosphorylation. Evidence is presented indicating that ets-2 can also act as a transcriptional repressor. In the breast cancer cell line MCF-7, exogenous ets-2 repressed the activity of a BRCA1 promoter-luciferase reporter dependent on a conserved ets-2-binding site in this promoter… CONTINUE READING