Ets-1 upregulates HER2-induced MMP-1 expression in breast cancer cells.


The human epidermal growth factor receptor-2 (HER2) plays an important role in breast cancer. Enhanced Ets-1 activity has recently been shown to be associated with breast cancer pathogenesis. To test the role of Ets-1 in breast cancer cells in relation to the expression of HER2 and MMP-1, we transiently overexpressed Ets-1 and/or HER2 in MCF-7 breast cancer… (More)
DOI: 10.1016/j.bbrc.2008.09.135


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