Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1.

@article{Kavurma2002Ets1PR,
  title={Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1.},
  author={Mary Meltem Kavurma and Yuri V Bobryshev and Levon M. Khachigian},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 39},
  pages={36244-52}
}
The FasL/Fas system has been implicated in smooth muscle cell apoptosis and atherosclerotic plaque instability, a process that can lead to plaque rupture, precipitating myocardial infarction and sudden death. The transcriptional mechanisms regulating FasL gene expression in vascular smooth muscle cells are poorly understood. We recently described a novel mechanism mediating inducible FasL gene expression in smooth muscle cells involving the zinc finger transcription factor Sp1 (Kavurma, M. M… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…