Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial

@article{Vermeire2014EtrolizumabAI,
  title={Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial},
  author={S{\'e}verine Vermeire and Sharon O’Byrne and Mary E. Keir and Marna B. Williams and Timothy T. Lu and John C Mansfield and Christopher Andrew Lamb and Brian G. Feagan and Juli{\'a}n Pan{\'e}s and Azucena Salas and Daniel C. Baumgart and Stefan Schreiber and Iris Dotan and William J Sandborn and Gaik Wei Tew and Diana Luca and M T Tang and Lauri Diehl and Jeffrey Eastham‐Anderson and Gert de Hertogh and Clémentine Perrier and Jackson G. Egen and John Andrew Kirby and Gert Van Van Assche and Paul J. Rutgeerts},
  journal={The Lancet},
  year={2014},
  volume={384},
  pages={309-318}
}
BACKGROUND Etrolizumab is a humanised monoclonal antibody that selectively binds the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. [...] Key MethodMETHODS In this double-blind, placebo-controlled, randomised, phase 2 study, patients with moderately-to-severely active ulcerative colitis who had not responded to conventional therapy were recruited from 40 referral centres in 11 countries.Expand
Etrolizumab in moderate-to-severe ulcerative colitis
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