Etoposide (VP-16) is a potent inducer of micronuclei in male rat meiosis: spermatid micronucleus test and DNA flow cytometry after etoposide treatment.

@article{Lhdetie1994EtoposideI,
  title={Etoposide (VP-16) is a potent inducer of micronuclei in male rat meiosis: spermatid micronucleus test and DNA flow cytometry after etoposide treatment.},
  author={Jaana L{\"a}hdetie and A Keiski and A Suutari and Jorma Toppari},
  journal={Environmental and molecular mutagenesis},
  year={1994},
  volume={24 3},
  pages={
          192-202
        }
}
The genotoxic and cytotoxic effects of etoposide (VP-16), a topoisomerase II inhibitor, on male rat spermatogenic cells were studied by analysing induction of micronuclei during meiosis. Micronuclei (MN) were scored in early spermatids after different time intervals corresponding to exposure of different stages of meiotic prophase. Etoposide had a strong effect on diplotene-diakinesis I cells harvested 1 day after exposure, and a significant effect also on late pachytene cells harvested 3 days… CONTINUE READING
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