Etoposide (VP-16) and cytosine arabinoside in the treatment of relapsed small-cell lung cancer.

Seventeen patients with small-cell lung cancer refractory to combination chemotherapy were entered in a study of VP-16 and infusional Ara-C. All patients were evaluable for response and 14 were evaluable for toxicity (three deaths that occurred after the first cycle of therapy were due to progressive tumor, and toxicity could not be evaluated in these three… CONTINUE READING