Etodolac activates and desensitizes transient receptor potential ankyrin 1

@article{Wang2013EtodolacAA,
  title={Etodolac activates and desensitizes transient receptor potential ankyrin 1},
  author={Shenglan Wang and Yi Dai and Yoko Kogure and Satoshi Yamamoto and Wensheng Zhang and Koichi Noguchi},
  journal={Journal of Neuroscience Research},
  year={2013},
  volume={91}
}
The transient receptor potential ankyrin 1 (TRPA1) channel is well known as a sensor to environmental irritant compounds, cold, and endogenous proalgesic agents. TRPA1 is expressed on sensory neurons and is involved in pain modulation. Etodolac is a cyclooxygenase (COX)‐2 inhibitor that belongs to the class of nonsteroidal anti‐inflammatory drugs (NSAIDs). A recent study indicates that etodolac inhibits allyl isothiocyanate (AITC)‐induced calcium influx in heterologous HEK293 cells and sensory… 
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Etodolac showed a selective TRPA1 agonist action, providing evidence that etodolacs desensitizes nociceptors by the selective activation of TRPA 1.
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