Etodolac Clinical Pharmacokinetics

@article{Brocks1994EtodolacCP,
  title={Etodolac Clinical Pharmacokinetics},
  author={Dion R. Brocks and Fakhreddin Jamali},
  journal={Clinical Pharmacokinetics},
  year={1994},
  volume={26},
  pages={259-274}
}
SummaryEtodolac is a chiral nonsteroidal anti-inflammatory drug (NSAID) that is marketed as the racemate. Currently, the drug is available in several countries for the treatment of arthritis and the alleviation of pain.Etodolac possesses several unique disposition features mainly due to its stereoselective pharmacokinetics. In plasma, the concentrations of the ‘inactive’ R-enantiomer are about 10-fold higher than those of the active S-enantiomer, an observation that is novel among the chiral… 
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It was showed that etodolac is well absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in thehorse.
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Ketorolac is a new chiral nonsteroidal anti-inflammatory drug (NSAID) which is marketed for analgesia as the racemate and has a volume of distribution comparable with those of other NSAIDs.
The Stereoselective Pharmacokinetics of Etodolac in Young and Elderly Subjects, and After Cholecystectomy
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In all subjects, the plasma concentrations of R‐etodolac, which is pharmacologically inactive, greatly exceeded those of the pharmacologically active S‐enantiomer, and the results reflect the importance of considering stereoselectivity in evaluating the pharmacokinetics of etodolacs.
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TLDR
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TLDR
The nonsteroidal anti-inflammatory agent etodolac (ET) exhibits stereoselectivity in its pharmacokinetics following administration to humans and rats, and the tissue distribution, in vitro tissue binding, and microsomal metabolism of ET enantiomers were studied in the rat.
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TLDR
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TLDR
Coadministration of an antacid, magaldrate, or the antiulcer agent, sucralfate, had no effect on the bioavailability of etodolac in dogs, although with the latter, a significant reduction in Cmax was noted.
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TLDR
The stereoselective pharmacokinetics of suprofen enantiomers has been studied in humans by means of stable isotope-labeled pseudoracemate-diastereomer methodology, including the estimation of chiral inversion after administration of the racemic mixture.
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