Etiopathogenesis of Otosclerosis

@article{Niedermeyer2002EtiopathogenesisOO,
  title={Etiopathogenesis of Otosclerosis},
  author={Hans Peter Niedermeyer and Wolfgang J. Arnold},
  journal={ORL},
  year={2002},
  volume={64},
  pages={114 - 119}
}
Otosclerosis is a frequent cause of nonsyndromic hearing loss which affects exclusively the human temporal bone. Various etiopathogenetic hypotheses have been proposed. The major hypotheses considered are genetic factors, immunologic factors and viral infection. Since the familial incidence of otosclerosis is known a recent genetic analysis has given evidence of three otosclerosis genes (OTSC1–3). Mutations in the collagen gene COL1A1 have been found in one large family with several cases of… Expand
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High-resolution computed tomography scan and MRI have played an important role in the diagnosis and therapeutic approach of otosclerosis and in assisting in the differential diagnosis. Expand
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TLDR
Two families are reported in which both otosclerosis and Meniere's disease are inherited as independent phenotypes suggesting that the two diseases represent different outcomes of the same mutation. Expand
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TLDR
The rationale for use of bisphosphonates to treat the sensorineural hearing loss of otosclerosis is explained, with cases that illustrate the bisph phosphonates treatment algorithms and the response to treatment. Expand
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TLDR
A 9-year-old boy presented to the clinic, suffering from moderate hearing loss, and a right exploratory tympanotomy was performed, finding bilateral secretory otitis media and the patient underwent bilateral grommet insertion. Expand
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