Etiology of Crohn’s disease: many roads lead to autophagy

  title={Etiology of Crohn’s disease: many roads lead to autophagy},
  author={Pierre Lapaquette and Patrick Brest and P. Hofman and Arlette Darfeuille-Michaud},
  journal={Journal of Molecular Medicine},
Crohn’s disease is a complex multifactor diseases that occur in individuals with genetic predisposition in whom environmental and microbial triggers cause a deleterious chronic immune response. Susceptibility to Crohn’s disease is influenced by common variants at many loci. Genetic studies have emphasized the role of host susceptibility in inflammatory bowel disease onset with the identification of about 100 risk loci, most of which encode proteins involved in immunity, host defense against… CONTINUE READING
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