Etiology-dependency of ionic remodeling in cardiomyopathic rabbits.


BACKGROUND Both dilated (DCM) and ischemic cardiomyopathy (ICM) are associated with action potential (AP) prolongation due to ionic remodeling. In humans, AP prolongation is more pronounced in myocytes isolated from explanted DCM than ICM hearts. However, there is a large variability due to confounding factors, including age, sex, concomitant disease, drug… (More)
DOI: 10.1016/j.ijcard.2009.10.047