Etiology and pathogenesis of the cohesinopathies

@inproceedings{Zakari2015EtiologyAP,
  title={Etiology and pathogenesis of the cohesinopathies},
  author={Musinu Zakari and Kobe C Yuen and Jennifer L Gerton},
  booktitle={Wiley interdisciplinary reviews. Developmental biology},
  year={2015}
}
Cohesin is a chromosome-associated protein complex that plays many important roles in chromosome function. Genetic screens in yeast originally identified cohesin as a key regulator of chromosome segregation. Subsequently, work by various groups has identified cohesin as critical for additional processes such as DNA damage repair, insulator function, gene regulation, and chromosome condensation. Mutations in the genes encoding cohesin and its accessory factors result in a group of developmental… CONTINUE READING

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How many roads lead to cohesinopathies?

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