Etiology and management of therapy-related myeloid leukemia.

  title={Etiology and management of therapy-related myeloid leukemia.},
  author={Richard A Larson},
  journal={Hematology. American Society of Hematology. Education Program},
The diagnosis of therapy-related myeloid leukemia (t-MDS/t-AML) identifies a group of high-risk patients with multiple and varied poor prognostic features. These neoplasms are thought to be the direct consequence of mutational events induced by cytotoxic therapy. Their outcomes have historically been poor compared with those of people who develop acute myeloid leukemia (AML) de novo. The question arises whether a diagnosis of t-AML per se indicates a poor prognosis, or whether their bad… CONTINUE READING
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( t - AML ) : an analysis of 93 patients with t - AML in comparison to 1091 patients with de novo AML

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